Larissa, the capital of the prefecture and of the entire region of Thessaly, lies on a site inhabited since the tenth millennium BC. A major commercial and industrial centre, the city is located in the middle of the plain of Thessaly, a few kilometres off the Athens-Thessaloniki National Road. Tradition has it that Hippocrates, the Father of Medicine, died here. The Alcazar park, the medieval fortress and the ancient theatre are worth a visit. Not to be missed, Larissa's Archaeological Museum houses rich collections of paleolithic and archaic artefacts. The Pinios River flowing through the town and its old mansions with their spacious courtyards and lush gardens give Larissa a charm of its own.

Other places worth seeing in the region is the green valley of Agia, the idyllic Stomio with its deep springs and Agiokambos with its enormous beach, ideal for summer holidays.